Version 5.4
Homo sapiens Gene: EIF4G1
Summary
InnateDB Gene IDBG-67809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4G1
Gene Name eukaryotic translation initiation factor 4 gamma, 1
Synonyms EIF-4G1; EIF4F; EIF4G; EIF4GI; P220; PARK18
Species Homo sapiens
Ensembl Gene ENSG00000114867
Encoded Proteins
IDBP-67811
eukaryotic translation initiation factor 4 gamma, 1
IDBP-67813
eukaryotic translation initiation factor 4 gamma, 1
IDBP-67815
eukaryotic translation initiation factor 4 gamma, 1
IDBP-67819
eukaryotic translation initiation factor 4 gamma, 1
IDBP-67821
eukaryotic translation initiation factor 4 gamma, 1
IDBP-67823
eukaryotic translation initiation factor 4 gamma, 1
IDBP-245422
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386102
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386106
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386107
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386108
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386110
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386115
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386116
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386118
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386119
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386121
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386123
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386124
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386125
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386126
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386127
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386129
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386130
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386132
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386134
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386135
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386137
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386139
eukaryotic translation initiation factor 4 gamma, 1
IDBP-386140
eukaryotic translation initiation factor 4 gamma, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5\'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:184314495-184335358
Strand Forward strand
Band q27.1
Transcripts
ENST00000350481 ENSP00000317600
ENST00000346169 ENSP00000316879
ENST00000352767 ENSP00000338020
ENST00000342981 ENSP00000343450
ENST00000319274 ENSP00000323737
ENST00000382330 ENSP00000371767
ENST00000392537 ENSP00000376320
ENST00000414031 ENSP00000391935
ENST00000444134 ENSP00000407244
ENST00000442406 ENSP00000400351
ENST00000450424 ENSP00000391412
ENST00000421110 ENSP00000413159
ENST00000413967 ENSP00000390755
ENST00000426123 ENSP00000403269
ENST00000455679 ENSP00000415842
ENST00000440448 ENSP00000407240
ENST00000427141 ENSP00000411214
ENST00000427845 ENSP00000407682
ENST00000424196 ENSP00000416255
ENST00000456033 ENSP00000415943
ENST00000411531 ENSP00000395974
ENST00000444861 ENSP00000398145
ENST00000441154 ENSP00000399858
ENST00000434061 ENSP00000411826
ENST00000428387 ENSP00000411707
ENST00000427607 ENSP00000409545
ENST00000457456 ENSP00000399969
ENST00000435046 ENSP00000404754
ENST00000448284 ENSP00000392908
ENST00000422614 ENSP00000396888
ENST00000485712
ENST00000484862
ENST00000493299
ENST00000466311
ENST00000482303
ENST00000460829
ENST00000475721
ENST00000464548
ENST00000478291
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 95 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0008219 cell death
GO:0008286 insulin receptor signaling pathway
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016281 eukaryotic translation initiation factor 4F complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045983
View Gene Order
ENSBTAG00000012881
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_6772
S6K1 signalling pathway
REACT_6754
S6K1-mediated signalling pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_25325
AUF1 (hnRNP D0) destabilizes mRNA pathway
REACT_20514
Deadenylation of mRNA pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_456
PKB-mediated events pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6964
mTORC1-mediated signalling pathway
REACT_1014
Translation pathway
REACT_111102
Signal Transduction pathway
REACT_25229
Interferon Signaling pathway
REACT_332
IRS-mediated signalling pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
KEGG
hsa05416
Viral myocarditis pathway
hsa03013
RNA transport pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.433750 Hs.605967
RefSeq NM_001194946 NM_001194947 NM_001291157 NM_004953 NM_182917 NM_198241 NM_198242 NM_198244
HUGO
OMIM
CCDS CCDS3259 CCDS3260 CCDS3261 CCDS46970 CCDS54687 CCDS54688
HPRD 06774
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca