Version 5.4
Homo sapiens Gene: MARCO
Summary
InnateDB Gene IDBG-67847.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCO
Gene Name macrophage receptor with collagenous structure
Synonyms SCARA2
Species Homo sapiens
Ensembl Gene ENSG00000019169
Encoded Proteins
IDBP-67849
macrophage receptor with collagenous structure
IDBP-385132
macrophage receptor with collagenous structure
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20162551
MARCO is upregulated in TLR4-mediated LPS responses and these receptors contribute to the efficient capturing and clearance of invading microbial pathogens.
InnateDB Annotation from Orthologs
Summary
PMID 24035364
[Mus musculus] Autophagy regulates phagocytosis by modulating the expression of scavenger receptors, Marco and Msr1
Entrez Gene
Summary The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:118942166-118994660
Strand Forward strand
Band q14.2
Transcripts
ENST00000327097 ENSP00000318916
ENST00000412481 ENSP00000409192
ENST00000494979
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005044 scavenger receptor activity
GO:0008329 signaling pattern recognition receptor activity
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0043277 apoptotic cell clearance
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005581 collagen trimer
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030666 endocytic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026390
View Gene Order
ENSBTAG00000018473
Not yet available
Pathways
NETPATH
REACTOME
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_163699
Scavenging by Class A Receptors pathway
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.67726
RefSeq NM_006770
HUGO
OMIM
CCDS CCDS2124
HPRD 05337
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca