Version 5.4
Homo sapiens Gene: EPC1
Summary
InnateDB Gene IDBG-67877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPC1
Gene Name enhancer of polycomb homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120616
Encoded Proteins
IDBP-67879
enhancer of polycomb homolog 1 (Drosophila)
IDBP-67881
enhancer of polycomb homolog 1 (Drosophila)
IDBP-67885
enhancer of polycomb homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:32267751-32378798
Strand Reverse strand
Band p11.22
Transcripts
ENST00000319778 ENSP00000318559
ENST00000375110 ENSP00000364251
ENST00000263062 ENSP00000263062
ENST00000492710
ENST00000476533
ENST00000479380
ENST00000495790
ENST00000480402
ENST00000469059
ENST00000462470
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0040008 regulation of growth
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0031965 nuclear membrane
GO:0032777 Piccolo NuA4 histone acetyltransferase complex
GO:0035267 NuA4 histone acetyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024240
View Gene Order
ENSBTAG00000001552
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.167805 Hs.597085 Hs.607750 Hs.671770 Hs.743354
RefSeq NM_001272004 NM_001272019 NM_001282391 NM_025209
HUGO
OMIM
CCDS CCDS60511 CCDS7172 CCDS73083
HPRD 09941
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca