InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF2S2

Summary

InnateDB Gene

IDBG-67889.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2S2

Gene Name

eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

Synonyms

eIF-2-beta; EIF2; EIF2B; EIF2beta; PPP1R67

Species

Homo sapiens

Ensembl Gene

ENSG00000125977

Encoded Proteins

IDBP-67891

eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:34088298-34112332

Strand

Reverse strand

Band

q11.22

Transcripts

ENST00000374980

ENSP00000364119

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002176	male germ cell proliferation
GO:0006412	translation
GO:0006413	translational initiation
GO:0008584	male gonad development
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process