Homo sapiens Gene: EIF2S2
Summary
InnateDB Gene IDBG-67889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2S2
Gene Name eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
Synonyms eIF-2-beta; EIF2; EIF2B; EIF2beta; PPP1R67;
Species Homo sapiens
Ensembl Gene ENSG00000125977
Encoded Proteins
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:34088298-34112332
Strand Reverse strand
Band q11.22
Transcripts
ENST00000374980 ENSP00000364119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 38 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0002176 male germ cell proliferation
GO:0006412 translation
GO:0006413 translational initiation
GO:0008584 male gonad development
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
GO:0005850 eukaryotic translation initiation factor 2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
Recycling of eIF2:GDP pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
Double stranded rna induced gene expression [Biocarta view]
Regulation of eif2 [Biocarta view]
Eukaryotic protein translation [Biocarta view]
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
PID NCI
Cross-References
SwissProt P20042
TrEMBL Q6IBR8 Q96I16
UniProt Splice Variant
Entrez Gene 8894
UniGene Hs.429180 Hs.662402 Hs.684089
RefSeq NM_003908
HUGO HGNC:3266
OMIM 603908
CCDS CCDS13231
HPRD
IMGT
EMBL AK313025 AL031668 BC000461 BC000934 BC007888 BT009795 CH471077 CR456734 M29536
GenPept AAA52383 AAH00461 AAH00934 AAH07888 AAP88797 BAG35860 CAB43741 CAG33015 EAW76285 EAW76286
RNA Seq Atlas 8894