Homo sapiens Gene: HIST1H2AC
Summary
InnateDB Gene IDBG-67915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H2AC
Gene Name histone cluster 1, H2ac
Synonyms dJ221C16.4; H2A/l; H2AFL;
Species Homo sapiens
Ensembl Gene ENSG00000180573
Encoded Proteins
histone cluster 1, H2ac
histone cluster 1, H2ac
histone cluster 1, H2ac
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26124145-26139116
Strand Forward strand
Band p22.2
Transcripts
ENST00000314088 ENSP00000321389
ENST00000377791 ENSP00000367022
ENST00000602637 ENSP00000473534
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 7 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0008150 biological_process
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Cellular responses to stress pathway
Packaging Of Telomere Ends pathway
PRC2 methylates histones and DNA pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNA Polymerase I Transcription pathway
Signaling by WNT in cancer pathway
Condensation of Prophase Chromosomes pathway
Signaling by Wnt pathway
Meiotic synapsis pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Telomere Maintenance pathway
Signal Transduction pathway
SIRT1 negatively regulates rRNA Expression pathway
Amyloids pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
HDACs deacetylate histones pathway
DNA methylation pathway
M Phase pathway
Cellular Senescence pathway
TCF dependent signaling in response to WNT pathway
Meiotic recombination pathway
Chromatin organization pathway
RNA Polymerase I Promoter Opening pathway
RNA Polymerase I Chain Elongation pathway
Mitotic Prophase pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Meiosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
KEGG
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q93077
TrEMBL A0A024R017 V9GZN0
UniProt Splice Variant
Entrez Gene 8334
UniGene Hs.622290 Hs.725428
RefSeq NM_003512
HUGO HGNC:4733
OMIM 602794
CCDS CCDS4585
HPRD 09104
IMGT
EMBL AK311811 AY131984 CH471087 K01889 U90551 U91328 Z80778
GenPept AAA35945 AAB53429 AAB82086 AAN59965 BAG34754 CAB02540 EAW55532 EAW55533
RNA Seq Atlas 8334