Homo sapiens Gene: ATP5H
Summary
InnateDB Gene IDBG-67931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5H
Gene Name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
Synonyms ATPQ;
Species Homo sapiens
Ensembl Gene ENSG00000167863
Encoded Proteins
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:75038863-75046985
Strand Reverse strand
Band q25.1
Transcripts
ENST00000301587 ENSP00000301587
ENST00000344546 ENSP00000344230
ENST00000538432 ENSP00000437996
ENST00000582341
ENST00000580649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0016887 ATPase activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006200 ATP catabolic process
GO:0015986 ATP synthesis coupled proton transport
GO:0022904 respiratory electron transport chain
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Formation of ATP by chemiosmotic coupling pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001003785 NM_006356
HUGO
OMIM
CCDS CCDS11712 CCDS32727
HPRD 16519
IMGT
EMBL
GenPept
RNA Seq Atlas