Version 5.4
Homo sapiens Gene: HIST1H2BD
Summary
InnateDB Gene IDBG-68028.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H2BD
Gene Name histone cluster 1, H2bd
Synonyms dJ221C16.6; H2B.1B; H2B/b; H2BFB; HIRIP2
Species Homo sapiens
Ensembl Gene ENSG00000158373
Encoded Proteins
IDBP-68030
histone cluster 1, H2bd
IDBP-68032
histone cluster 1, H2bd
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26158146-26171349
Strand Forward strand
Band p22.2
Transcripts
ENST00000289316 ENSP00000289316
ENST00000377777 ENSP00000367008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_7963
Packaging Of Telomere Ends pathway
REACT_75925
Amyloids pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_2232
RNA Polymerase I Promoter Opening pathway
REACT_27271
Meiotic recombination pathway
REACT_172610
HATs acetylate histones pathway
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_11045
Signaling by Wnt pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_7970
Telomere Maintenance pathway
REACT_111102
Signal Transduction pathway
REACT_200827
SIRT1 negatively regulates rRNA Expression pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_267652
DNA methylation pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172623
Chromatin organization pathway
REACT_765
Mitotic Prophase pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_111183
Meiosis pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
hsa05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Cross-References
SwissProt P58876
TrEMBL A0A024QZZ7
UniProt Splice Variant
Entrez Gene 3017
UniGene Hs.591797
RefSeq NM_021063 NM_138720
HUGO HGNC:4747
OMIM 602799
CCDS CCDS4587
HPRD 07535
IMGT
EMBL AF531287 AJ223353 AL353759 BC002842 CH471087 M60751
GenPept AAA63190 AAH02842 AAN06687 CAA11277 CAC04133 EAW55535 EAW55536
RNA Seq Atlas 3017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca