InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AHCY

Summary

InnateDB Gene

IDBG-68065.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AHCY

Gene Name

adenosylhomocysteinase

Synonyms

adoHcyase; SAHH

Species

Homo sapiens

Ensembl Gene

ENSG00000101444

Encoded Proteins

IDBP-68067

adenosylhomocysteinase

IDBP-594537

adenosylhomocysteinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:34280268-34311802

Strand

Reverse strand

Band

q11.22

Transcripts

ENST00000217426	ENSP00000217426
ENST00000480653
ENST00000468908
ENST00000473516
ENST00000538132	ENSP00000442820
ENST00000606061

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.

Experimentally validated
Total	59 [view]
Protein-Protein	59 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004013	adenosylhomocysteinase activity
GO:0004455	ketol-acid reductoisomerase activity
GO:0051287	NAD binding

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006730	one-carbon metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0032259	methylation
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027597

View Gene Order

ENSBTAG00000018101

Not yet available

Pathways

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_115639

Sulfur amino acid metabolism pathway

REACT_6946

Methylation pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00270

Cysteine and methionine metabolism pathway

INOH

INOH website

Methionine Cysteine metabolism pathway

PID NCI

Cross-References

SwissProt

P23526

TrEMBL

Q1RMG2

UniProt Splice Variant

Entrez Gene

191

UniGene

Hs.388004 Hs.608390

RefSeq

NM_001161766 XM_005260316 XM_005260317 NM_000687

HUGO

HGNC:343

OMIM

180960

CCDS

CCDS54457 CCDS13233

HPRD

01621

IMGT

EMBL

AK097610 AK290422 AK300014 AK316180 AL356299 BC010018 BC011606 BC114924 BT006697 CH471077 M61831 M61832

GenPept

AAA51681 AAA51682 AAH10018 AAH11606 AAI14925 AAP35343 BAF83111 BAG53495 BAG61829 BAH14551 CAC09528 EAW76279 EAW76280

RNA Seq Atlas

191