Homo sapiens Gene: DNAJB11
Summary
InnateDB Gene IDBG-68896.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJB11
Gene Name DnaJ (Hsp40) homolog, subfamily B, member 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000090520
Encoded Proteins
DnaJ (Hsp40) homolog, subfamily B, member 11
DnaJ (Hsp40) homolog, subfamily B, member 11
DnaJ (Hsp40) homolog, subfamily B, member 11
DnaJ (Hsp40) homolog, subfamily B, member 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DNAJB11 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a C-terminal cysteine-rich region (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:186567403-186597203
Strand Forward strand
Band q27.3
Transcripts
ENST00000265028 ENSP00000265028
ENST00000439351 ENSP00000414398
ENST00000418776 ENSP00000408410
ENST00000464877
ENST00000495390
ENST00000538831 ENSP00000440189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 77 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0016556 mRNA modification
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
XBP1(S) activates chaperone genes pathway
Metabolism of proteins pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F5GXK8
UniProt Splice Variant
Entrez Gene 51726
UniGene Hs.317192 Hs.601927 Hs.621619 Hs.734774 Hs.738892
RefSeq NM_016306
HUGO HGNC:14889
OMIM 611341
CCDS CCDS3277
HPRD 07485
IMGT
EMBL AC068631
GenPept
RNA Seq Atlas 51726