Version 5.4
Homo sapiens Gene: HRG
Summary
InnateDB Gene IDBG-69039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRG
Gene Name histidine-rich glycoprotein
Synonyms HPRG; HRGP; THPH11
Species Homo sapiens
Ensembl Gene ENSG00000113905
Encoded Proteins
IDBP-69041
histidine-rich glycoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21757718
HRG binds fibrinogen with high affinity and competes with thrombin for binding. This interaction may provide a novel link between coagulation, innate immunity and inflammation.
InnateDB Annotation from Orthologs
Summary
PMID 21757718
[Mus musculus] Hrg binds fibrinogen with high affinity and competes with thrombin for binding. This interaction may provide a novel link between coagulation, innate immunity and inflammation. (Demonstrated in human)
Entrez Gene
Summary This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Jul 2008]
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein\'s effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:186660216-186678240
Strand Forward strand
Band q27.3
Transcripts
ENST00000232003 ENSP00000232003
ENST00000468154
ENST00000495413
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0019865 immunoglobulin binding
GO:0020037 heme binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0002576 platelet degranulation
GO:0002839 positive regulation of immune response to tumor cell
GO:0006935 chemotaxis
GO:0007162 negative regulation of cell adhesion
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010543 regulation of platelet activation
GO:0010593 negative regulation of lamellipodium assembly
GO:0010951 negative regulation of endopeptidase activity
GO:0014070 response to organic cyclic compound
GO:0015886 heme transport
GO:0016525 negative regulation of angiogenesis
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030308 negative regulation of cell growth
GO:0032956 regulation of actin cytoskeleton organization
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron
GO:0042730 fibrinolysis
GO:0043065 positive regulation of apoptotic process
GO:0043254 regulation of protein complex assembly
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050832 defense response to fungus
GO:0051894 positive regulation of focal adhesion assembly
GO:0051918 negative regulation of fibrinolysis
GO:0097037 heme export
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:2000504 positive regulation of blood vessel remodeling
GO:2001027 negative regulation of endothelial cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0031093 platelet alpha granule lumen
GO:0031982 vesicle
GO:0036019 endolysosome
GO:0061474 phagolysosome membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022877
View Gene Order
ENSBTAG00000001265
Not yet available
Pathways
NETPATH
REACTOME
REACT_641
Dissolution of Fibrin Clot pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P04196
TrEMBL
UniProt Splice Variant
Entrez Gene 3273
UniGene Hs.1498
RefSeq NM_000412
HUGO HGNC:5181
OMIM 142640
CCDS CCDS3280
HPRD 00812
IMGT
EMBL AB005803 BC069574 BC150591 CH471052 M13149 Z17218
GenPept AAA52694 AAH69574 AAI50592 BAA21613 CAA78925 EAW78183 EAW78184
RNA Seq Atlas 3273

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca