Version 5.4
| Homo sapiens Gene: PROC | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-69078.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PROC | ||||||||||||||||||
| Gene Name | protein C (inactivator of coagulation factors Va and VIIIa) | ||||||||||||||||||
| Synonyms | APC; PC; PROC1; THPH3; THPH4 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000115718 | ||||||||||||||||||
| Encoded Proteins |
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 2:127418427-127429246 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q14.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Cell surface interactions at the vascular wall pathway
Intrinsic Pathway pathway
Common Pathway pathway
Gamma-carboxylation of protein precursors pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Post-translational protein modification pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Metabolism of proteins pathway
Hemostasis pathway
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| KEGG |
Complement and coagulation cascades pathway
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| INOH | |||||||||||||||||||
| PID NCI |
Beta2 integrin cell surface interactions
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.224698 | ||||||||||||||||||
| RefSeq | NM_000312 XM_005263715 XM_005263716 XM_005263717 XM_006712633 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS2145 | ||||||||||||||||||
| HPRD | 01466 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||