Homo sapiens Gene: PROC
Summary
InnateDB Gene IDBG-69078.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROC
Gene Name protein C (inactivator of coagulation factors Va and VIIIa)
Synonyms APC; PC; PROC1; THPH3; THPH4;
Species Homo sapiens
Ensembl Gene ENSG00000115718
Encoded Proteins
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
protein C (inactivator of coagulation factors Va and VIIIa)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:127418427-127429246
Strand Forward strand
Band q14.3
Transcripts
ENST00000234071 ENSP00000234071
ENST00000409048 ENSP00000386679
ENST00000402125 ENSP00000384225
ENST00000419985 ENSP00000392606
ENST00000429925 ENSP00000412697
ENST00000442644 ENSP00000411241
ENST00000427769 ENSP00000406295
ENST00000431364 ENSP00000391220
ENST00000474030
ENST00000464089
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0017187 peptidyl-glutamic acid carboxylation
GO:0030195 negative regulation of blood coagulation
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0050900 leukocyte migration
Cellular Component
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Metabolism of proteins pathway
Intrinsic Pathway pathway
Common Pathway pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation of protein precursors pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
Extrinsic prothrombin activation pathway [Biocarta view]
Segmentation clock [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Tgf beta signaling pathway [Biocarta view]
Intrinsic prothrombin activation pathway [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL E7ENR9 E7EU72 E7EVH6
UniProt Splice Variant
Entrez Gene 5624
UniGene Hs.224698
RefSeq NM_000312 XM_005263715 XM_005263716 XM_005263717 XM_006712633
HUGO HGNC:9451
OMIM 612283
CCDS CCDS2145
HPRD 01466
IMGT
EMBL AC068282
GenPept
RNA Seq Atlas 5624