Homo sapiens Gene: RFC4 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-69139.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | RFC4 | ||||||||||||||||||||||||
Gene Name | replication factor C (activator 1) 4, 37kDa | ||||||||||||||||||||||||
Synonyms | A1; RFC37 | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000163918 | ||||||||||||||||||||||||
Encoded Proteins |
replication factor C (activator 1) 4, 37kDa
replication factor C (activator 1) 4, 37kDa
replication factor C (activator 1) 4, 37kDa
replication factor C (activator 1) 4, 37kDa
replication factor C (activator 1) 4, 37kDa
replication factor C (activator 1) 4, 37kDa
replication factor C (activator 1) 4, 37kDa
replication factor C (activator 1) 4, 37kDa
replication factor C (activator 1) 4, 37kDa
replication factor C (activator 1) 4, 37kDa
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 3:186789880-186807058 | ||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||
Band | q27.3 | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
Activation of ATR in response to replication stress pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Polymerase switching pathway
Leading Strand Synthesis pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
DNA Replication pathway
Synthesis of DNA pathway
S Phase pathway
Chromosome Maintenance pathway
G2/M Checkpoints pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
DNA Repair pathway
Cell Cycle Checkpoints pathway
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KEGG |
DNA replication pathway
Nucleotide excision repair pathway
Mismatch repair pathway
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INOH | |||||||||||||||||||||||||
PID NCI |
Fanconi anemia pathway
ATR signaling pathway
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Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
UniGene | Hs.671735 Hs.732098 | ||||||||||||||||||||||||
RefSeq | NM_002916 NM_181573 | ||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS3283 | ||||||||||||||||||||||||
HPRD | 00022 | ||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||