InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MMP10

Summary

InnateDB Gene

IDBG-69194.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP10

Gene Name

matrix metallopeptidase 10 (stromelysin 2)

Synonyms

SL-2; STMY2

Species

Homo sapiens

Ensembl Gene

ENSG00000166670

Encoded Proteins

IDBP-69196

matrix metallopeptidase 10 (stromelysin 2)

IDBP-591507

matrix metallopeptidase 10 (stromelysin 2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102770503-102780628

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000279441	ENSP00000279441
ENST00000539681	ENSP00000441485

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030334	regulation of cell migration
GO:0030574	collagen catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000047562

View Gene Order

Pathways

NETPATH

REACTOME

REACT_118682

Activation of Matrix Metalloproteinases pathway

REACT_150401

Collagen degradation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.2258

RefSeq

NM_002425

HUGO

OMIM

CCDS

CCDS8321

HPRD

01704

IMGT

EMBL

GenPept

RNA Seq Atlas