Version 5.4
Homo sapiens Gene: LPP
Summary
InnateDB Gene IDBG-69427.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPP
Gene Name LIM domain containing preferred translocation partner in lipoma
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145012
Encoded Proteins
IDBP-386522
LIM domain containing preferred translocation partner in lipoma
IDBP-386523
LIM domain containing preferred translocation partner in lipoma
IDBP-386524
LIM domain containing preferred translocation partner in lipoma
IDBP-386526
LIM domain containing preferred translocation partner in lipoma
IDBP-386529
LIM domain containing preferred translocation partner in lipoma
IDBP-386532
LIM domain containing preferred translocation partner in lipoma
IDBP-386534
LIM domain containing preferred translocation partner in lipoma
IDBP-386536
LIM domain containing preferred translocation partner in lipoma
IDBP-386537
LIM domain containing preferred translocation partner in lipoma
IDBP-386539
LIM domain containing preferred translocation partner in lipoma
IDBP-809864
LIM domain containing preferred translocation partner in lipoma
IDBP-809869
LIM domain containing preferred translocation partner in lipoma
IDBP-809870
LIM domain containing preferred translocation partner in lipoma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of chimeric proteins that may promote tumor growth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:188153284-188890671
Strand Forward strand
Band q27.3
Transcripts
ENST00000448637 ENSP00000393602
ENST00000416784 ENSP00000410340
ENST00000430340 ENSP00000397166
ENST00000414139 ENSP00000392667
ENST00000454789 ENSP00000394257
ENST00000426274 ENSP00000397017
ENST00000420410 ENSP00000405138
ENST00000443217 ENSP00000404679
ENST00000457242 ENSP00000403825
ENST00000415906 ENSP00000393008
ENST00000494233
ENST00000474472
ENST00000484468
ENST00000462758
ENST00000471917
ENST00000487347
ENST00000483938
ENST00000494044
ENST00000459897
ENST00000618621 ENSP00000482617
ENST00000616304 ENSP00000482472
ENST00000617246 ENSP00000478901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007155 cell adhesion
GO:0008150 biological_process
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033306
View Gene Order
ENSBTAG00000044001
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt Q93052
TrEMBL B7Z871 C9J1K7 C9J2R5 C9J3U9 C9J4E3 C9J5C8 C9JE51 C9JIY7 C9JT42
UniProt Splice Variant
Entrez Gene 4026
UniGene
RefSeq NM_005578 XM_005247444 XM_005247445 XM_005247446 XM_005247447 XM_005247448 XM_005247451 XM_005247453 XM_006713637 NM_001167671 NM_001167672
HUGO HGNC:6679
OMIM 600700
CCDS CCDS3291
HPRD
IMGT
EMBL AC009319 AC022498 AC055711 AC063932 AC069226 AC069430 AC117507 AF393503 AK302959 BC130584 CH471052 CR457074 U49957 U49960 U49961 U49962 U49963 U49964 U49965 U49966 U49967 U49968
GenPept AAC50738 AAC50739 AAI30585 AAM73685 BAH13857 CAG33355 EAW78127 EAW78128 EAW78133
RNA Seq Atlas 4026

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca