Homo sapiens Gene: MMP24
Summary
InnateDB Gene IDBG-69520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMP24
Gene Name matrix metallopeptidase 24 (membrane-inserted)
Synonyms MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP; MT5MMP; MTMMP5;
Species Homo sapiens
Ensembl Gene ENSG00000125966
Encoded Proteins
matrix metallopeptidase 24 (membrane-inserted)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:35226654-35277000
Strand Forward strand
Band q11.22
Transcripts
ENST00000246186 ENSP00000246186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008047 enzyme activator activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005887 integral component of plasma membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Activation of Matrix Metalloproteinases pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y5R2
TrEMBL Q86VV6
UniProt Splice Variant
Entrez Gene 10893
UniGene Hs.715494 Hs.732566
RefSeq NM_006690
HUGO HGNC:7172
OMIM 604871
CCDS CCDS46593
HPRD 05338
IMGT
EMBL AB021227 AF131284 AL121753 BC047614
GenPept AAD42962 AAH47614 BAA82967 CAX12722
RNA Seq Atlas 10893