InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CASP4

Summary

InnateDB Gene

IDBG-69557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP4

Gene Name

caspase 4, apoptosis-related cysteine peptidase

Synonyms

ICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX

Species

Homo sapiens

Ensembl Gene

ENSG00000196954

Encoded Proteins

IDBP-244203

caspase 4, apoptosis-related cysteine peptidase

IDBP-382632

caspase 4, apoptosis-related cysteine peptidase

IDBP-382637

caspase 4, apoptosis-related cysteine peptidase

IDBP-584761

caspase 4, apoptosis-related cysteine peptidase

IDBP-809077

caspase 4, apoptosis-related cysteine peptidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25964352

CASP4 is a critical regulator of noncanonical inflammasome activation that initiates defence against bacterial pathogens in primary macrophages by mediating cell death and IL1A release

Entrez Gene

Summary

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:104942866-104969436

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000393150	ENSP00000376857
ENST00000444739	ENSP00000388566
ENST00000417440	ENSP00000401673
ENST00000525116
ENST00000533252	ENSP00000432879
ENST00000529565
ENST00000530309
ENST00000533730
ENST00000534356
ENST00000529183
ENST00000524843
ENST00000531333
ENST00000531546
ENST00000613196	ENSP00000482808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0072557	IPAF inflammasome complex
GO:0072559	NLRP3 inflammasome complex
GO:0097169	AIM2 inflammasome complex

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_75776

NOD1/2 Signaling Pathway pathway

REACT_6802

Innate Immune System pathway

REACT_75913

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.138378 Hs.593209 Hs.682353

RefSeq

NM_001225 NM_033306

HUGO

OMIM

CCDS

CCDS41704 CCDS8327

HPRD

04047

IMGT

EMBL

GenPept

RNA Seq Atlas