Homo sapiens Gene: PTPN18
Summary
InnateDB Gene IDBG-69787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN18
Gene Name protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072135
Encoded Proteins
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:130356007-130375409
Strand Forward strand
Band q21.1
Transcripts
ENST00000175756 ENSP00000175756
ENST00000347849 ENSP00000310092
ENST00000409022 ENSP00000387031
ENST00000428843 ENSP00000411750
ENST00000420717
ENST00000489215
ENST00000483617
ENST00000479295
ENST00000460992
ENST00000495400
ENST00000490812
ENST00000462996
ENST00000464576
ENST00000490137
ENST00000481492
ENST00000462321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
BCR pathway
TSLP pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516390 Hs.743240
RefSeq NM_001142370 NM_014369 XM_006712415
HUGO
OMIM
CCDS CCDS2161 CCDS46410
HPRD 05961
IMGT
EMBL
GenPept
RNA Seq Atlas