Homo sapiens Gene: FGF12
Summary
InnateDB Gene IDBG-69854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF12
Gene Name fibroblast growth factor 12
Synonyms FGF12B; FHF1;
Species Homo sapiens
Ensembl Gene ENSG00000114279
Encoded Proteins
fibroblast growth factor 12
fibroblast growth factor 12
fibroblast growth factor 12
fibroblast growth factor 12
fibroblast growth factor 12
fibroblast growth factor 12
fibroblast growth factor 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:192139395-192767764
Strand Reverse strand
Band q29
Transcripts
ENST00000454309 ENSP00000413496
ENST00000445105 ENSP00000393686
ENST00000440901 ENSP00000400948
ENST00000450716 ENSP00000397635
ENST00000430714 ENSP00000410125
ENST00000448795 ENSP00000412904
ENST00000418610 ENSP00000395517
ENST00000466144
ENST00000491636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0017080 sodium channel regulator activity
GO:0044325 ion channel binding
Biological Process
GO:0003254 regulation of membrane depolarization
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0007267 cell-cell signaling
GO:0007268 synaptic transmission
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008344 adult locomotory behavior
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010765 positive regulation of sodium ion transport
GO:0050905 neuromuscular process
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:1902305 regulation of sodium ion transmembrane transport
GO:2000649 regulation of sodium ion transmembrane transporter activity
GO:2001258 negative regulation of cation channel activity
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
MAPK signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Melanoma pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P61328
TrEMBL C9JEN8 C9JIN3 C9JUK8 H7C1L8
UniProt Splice Variant
Entrez Gene 2257
UniGene Hs.390250 Hs.584758
RefSeq NM_004113 NM_021032 XM_005247227 XM_006713538 XM_006713539
HUGO HGNC:3668
OMIM 601513
CCDS CCDS3301 CCDS46983
HPRD
IMGT
EMBL AC026671 AC073363 AC079623 AC079847 AC128710 AK125307 AK312513 AK313671 BC022524 CH471052 U66197 U76381
GenPept AAB18786 AAB18913 AAH22524 BAG35414 BAG36423 BAG54181 EAW78084
RNA Seq Atlas 2257