InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHP1

Summary

InnateDB Gene

IDBG-6990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHP1

Gene Name

calcineurin-like EF hand protein 1

Synonyms

CHP; p22; p24; Sid470p; SLC9A1BP

Species

Homo sapiens

Ensembl Gene

ENSG00000187446

Encoded Proteins

IDBP-6992

Calcium-binding protein p22

IDBP-603785

Calcium-binding protein p22

IDBP-590679

Calcium-binding protein p22

IDBP-596688

Calcium-binding protein p22

IDBP-600512

Calcium-binding protein p22

IDBP-592532

Calcium-binding protein p22

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:41230839-41281890

Strand

Forward strand

Band

q15.1

Transcripts

ENST00000334660	ENSP00000335632
ENST00000392151	ENSP00000440490
ENST00000558351
ENST00000560411	ENSP00000453375
ENST00000560784	ENSP00000452772
ENST00000561280
ENST00000560397	ENSP00000454007
ENST00000560633
ENST00000560965	ENSP00000453392

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015459	potassium channel regulator activity
GO:0019900	kinase binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001578	microtubule bundle formation
GO:0001933	negative regulation of protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0006611	protein export from nucleus
GO:0006813	potassium ion transport
GO:0007264	small GTPase mediated signal transduction
GO:0010923	negative regulation of phosphatase activity
GO:0017156	calcium ion-dependent exocytosis
GO:0022406	membrane docking
GO:0031122	cytoplasmic microtubule organization
GO:0031397	negative regulation of protein ubiquitination
GO:0031953	negative regulation of protein autophosphorylation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032417	positive regulation of sodium:proton antiporter activity
GO:0042308	negative regulation of protein import into nucleus
GO:0045056	transcytosis
GO:0050821	protein stabilization
GO:0051222	positive regulation of protein transport
GO:0051259	protein oligomerization
GO:0051453	regulation of intracellular pH
GO:0060050	positive regulation of protein glycosylation
GO:0061024	membrane organization
GO:0061025	membrane fusion
GO:0070885	negative regulation of calcineurin-NFAT signaling cascade
GO:0071468	cellular response to acidity
GO:0090314	positive regulation of protein targeting to membrane

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0030133	transport vesicle
GO:0070062	extracellular vesicular exosome