Homo sapiens Gene: BRAT1
Summary
InnateDB Gene IDBG-7009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRAT1
Gene Name BRCA1-associated ATM activator 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000106009
Encoded Proteins
BRCA1-associated ATM activator 1
BRCA1-associated ATM activator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:2537877-2555727
Strand Reverse strand
Band p22.3
Transcripts
ENST00000340611 ENSP00000339637
ENST00000421712 ENSP00000409209
ENST00000469750
ENST00000467558
ENST00000493232
ENST00000473879
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0010212 response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q6PJG6
TrEMBL F8WDN5
UniProt Splice Variant
Entrez Gene 221927
UniGene Hs.520623
RefSeq NM_152743
HUGO HGNC:21701
OMIM 614506
CCDS CCDS5334
HPRD
IMGT
EMBL AC092488 AK024482 AL133088 BC007209 BC015632 BC023561 BC040704 CH236953 CH471144
GenPept AAH07209 AAH15632 AAH23561 AAH40704 BAB15772 CAB61405 EAL23957 EAW87257 EAW87258
RNA Seq Atlas 221927