Version 5.4
Homo sapiens Gene: CUL5
Summary
InnateDB Gene IDBG-70098.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CUL5
Gene Name cullin 5
Synonyms VACM-1; VACM1
Species Homo sapiens
Ensembl Gene ENSG00000166266
Encoded Proteins
IDBP-244306
cullin 5
IDBP-587969
cullin 5
IDBP-588532
cullin 5
IDBP-584754
cullin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:108008733-108107776
Strand Forward strand
Band q22.3
Transcripts
ENST00000393094 ENSP00000376808
ENST00000532064 ENSP00000436494
ENST00000526303
ENST00000531427 ENSP00000435376
ENST00000532782 ENSP00000431221
ENST00000531843
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 454 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 454 [view]
Protein-Protein 452 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006970 response to osmotic stress
GO:0007050 cell cycle arrest
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0051480 cytosolic calcium ion homeostasis
GO:0070588 calcium ion transmembrane transport
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031466 Cul5-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032030
View Gene Order
ENSBTAG00000012882
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_9453
Vif-mediated degradation of APOBEC3G pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.440320 Hs.679672 Hs.732754 Hs.741738
RefSeq NM_003478
HUGO
OMIM
CCDS CCDS31668
HPRD 03444
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca