Homo sapiens Gene: HES1
InnateDB Gene IDBG-70185.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HES1
Gene Name hairy and enhancer of split 1, (Drosophila)
Synonyms bHLHb39; HES-1; HHL; HRY;
Species Homo sapiens
Ensembl Gene ENSG00000114315
Encoded Proteins
hairy and enhancer of split 1, (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:194136145-194138732
Strand Forward strand
Band q29
ENST00000232424 ENSP00000232424
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 49 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 1 [view]
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
GO:0071820 N-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0003143 embryonic heart tube morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003281 ventricular septum development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0007155 cell adhesion
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007262 STAT protein import into nucleus
GO:0007389 pattern specification process
GO:0007399 nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0016477 cell migration
GO:0021537 telencephalon development
GO:0021555 midbrain-hindbrain boundary morphogenesis
GO:0021557 oculomotor nerve development
GO:0021558 trochlear nerve development
GO:0021575 hindbrain morphogenesis
GO:0021861 forebrain radial glial cell differentiation
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0021984 adenohypophysis development
GO:0030324 lung development
GO:0030513 positive regulation of BMP signaling pathway
GO:0030901 midbrain development
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0035019 somatic stem cell maintenance
GO:0035909 aorta morphogenesis
GO:0035910 ascending aorta morphogenesis
GO:0042102 positive regulation of T cell proliferation
GO:0042491 auditory receptor cell differentiation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668 auditory receptor cell fate determination
GO:0043388 positive regulation of DNA binding
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045608 negative regulation of auditory receptor cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045977 positive regulation of mitotic cell cycle, embryonic
GO:0046331 lateral inhibition
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048469 cell maturation
GO:0048505 regulation of timing of cell differentiation
GO:0048538 thymus development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048844 artery morphogenesis
GO:0050767 regulation of neurogenesis
GO:0060164 regulation of timing of neuron differentiation
GO:0060253 negative regulation of glial cell proliferation
GO:0060412 ventricular septum morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060716 labyrinthine layer blood vessel development
GO:0061009 common bile duct development
GO:0061106 negative regulation of stomach neuroendocrine cell differentiation
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061626 pharyngeal arch artery morphogenesis
GO:0072012 glomerulus vasculature development
GO:0072049 comma-shaped body morphogenesis
GO:0072050 S-shaped body morphogenesis
GO:0072141 renal interstitial cell development
GO:0072282 metanephric nephron tubule morphogenesis
GO:0090102 cochlea development
GO:0097084 vascular smooth muscle cell development
GO:0097150 neuronal stem cell maintenance
GO:2000227 negative regulation of pancreatic A cell differentiation
GO:2000737 negative regulation of stem cell differentiation
GO:2000974 negative regulation of pro-B cell differentiation
GO:2000978 negative regulation of forebrain neuron differentiation
GO:2000981 negative regulation of inner ear receptor cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Notch pathway
ID pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Developmental Biology pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by NOTCH1 in Cancer pathway
Regulation of beta-cell development pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
NOTCH2 intracellular domain regulates transcription pathway
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Notch signaling pathway pathway
Maturity onset diabetes of the young pathway
Segmentation clock [Biocarta view]
Fanconi anemia pathway
ATF-2 transcription factor network
Notch-mediated HES/HEY network
C-MYB transcription factor network
Validated transcriptional targets of deltaNp63 isoforms
UniProt Splice Variant
Entrez Gene
UniGene Hs.250666 Hs.601540
RefSeq NM_005524
HPRD 00770
RNA Seq Atlas