Homo sapiens Gene: HSPBP1
Summary
InnateDB Gene IDBG-70495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPBP1
Gene Name HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Synonyms FES1;
Species Homo sapiens
Ensembl Gene ENSG00000133265
Encoded Proteins
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
HSPBP1 interacts with PGLYRP1 and inhibits the cytotoxic activity of the HSPA1A :: PGLYRP1 complex secreted by lymphocytes.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Hspbp1 interacts with Pglyrp1 and inhibits the cytotoxic activity of the Hspa1a :: Pglyrp1 complex secreted by lymphocytes.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55262231-55280381
Strand Reverse strand
Band q13.42
Transcripts
ENST00000255631 ENSP00000255631
ENST00000433386 ENSP00000398244
ENST00000588971 ENSP00000468403
ENST00000587959 ENSP00000466749
ENST00000587922 ENSP00000467574
ENST00000585927 ENSP00000466569
ENST00000587551 ENSP00000467926
ENST00000585698 ENSP00000465690
ENST00000593263 ENSP00000465876
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006457 protein folding
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043086 negative regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.53066 Hs.739276
RefSeq NM_001130106 NM_001297600 NM_012267 XM_005258700 XM_005258701
HUGO
OMIM
CCDS CCDS33111
HPRD 09991
IMGT
EMBL
GenPept
RNA Seq Atlas