Version 5.4
Homo sapiens Gene: HSPBP1
Summary
InnateDB Gene IDBG-70495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPBP1
Gene Name HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Synonyms FES1
Species Homo sapiens
Ensembl Gene ENSG00000133265
Encoded Proteins
IDBP-70497
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IDBP-385355
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IDBP-763712
IDBP-760841
IDBP-763555
IDBP-760054
IDBP-764984
IDBP-762155
IDBP-764926
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21247889
HSPBP1 interacts with PGLYRP1 and inhibits the cytotoxic activity of the HSPA1A :: PGLYRP1 complex secreted by lymphocytes.
InnateDB Annotation from Orthologs
Summary
PMID 21247889
[Mus musculus] Hspbp1 interacts with Pglyrp1 and inhibits the cytotoxic activity of the Hspa1a :: Pglyrp1 complex secreted by lymphocytes.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55262231-55280381
Strand Reverse strand
Band q13.42
Transcripts
ENST00000255631 ENSP00000255631
ENST00000433386 ENSP00000398244
ENST00000588971 ENSP00000468403
ENST00000587959 ENSP00000466749
ENST00000587922 ENSP00000467574
ENST00000585927 ENSP00000466569
ENST00000587551 ENSP00000467926
ENST00000585698 ENSP00000465690
ENST00000593263 ENSP00000465876
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006457 protein folding
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043086 negative regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063802
View Gene Order
ENSBTAG00000003644
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.53066 Hs.739276
RefSeq NM_001130106 NM_001297600 NM_012267 XM_005258700 XM_005258701
HUGO
OMIM
CCDS CCDS33111
HPRD 09991
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca