Version 5.4
Homo sapiens Gene: RTF1
Summary
InnateDB Gene IDBG-7053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTF1
Gene Name Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Synonyms GTL7; KIAA0252
Species Homo sapiens
Ensembl Gene ENSG00000137815
Encoded Proteins
IDBP-7059
Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
IDBP-584475
Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:41408408-41483563
Strand Forward strand
Band q15.1
Transcripts
ENST00000389629 ENSP00000374280
ENST00000462276
ENST00000473214
ENST00000558298
ENST00000560447 ENSP00000452973
ENST00000558117
ENST00000561076
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 34 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001711 endodermal cell fate commitment
GO:0006352 DNA-templated transcription, initiation
GO:0016055 Wnt signaling pathway
GO:0016570 histone modification
GO:0019827 stem cell maintenance
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0080182 histone H3-K4 trimethylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016593 Cdc73/Paf1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027304
View Gene Order
ENSBTAG00000001671
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.511096
RefSeq NM_015138
HUGO
OMIM
CCDS CCDS32200
HPRD 11071
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca