InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL28

Summary

InnateDB Gene

IDBG-70679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL28

Gene Name

ribosomal protein L28

Synonyms

L28

Species

Homo sapiens

Ensembl Gene

ENSG00000108107

Encoded Proteins

IDBP-70681

ribosomal protein L28

IDBP-385413

ribosomal protein L28

IDBP-385414

ribosomal protein L28

IDBP-589847

ribosomal protein L28

IDBP-602725

ribosomal protein L28

IDBP-592621

ribosomal protein L28

IDBP-589431

ribosomal protein L28

IDBP-592054

ribosomal protein L28

IDBP-586217

ribosomal protein L28

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:55385345-55403250

Strand

Forward strand

Band

q13.42

Transcripts

ENST00000344063	ENSP00000342787
ENST00000426763
ENST00000428193	ENSP00000391665
ENST00000431533	ENSP00000400596
ENST00000558815	ENSP00000452909
ENST00000560583	ENSP00000453029
ENST00000560055	ENSP00000452763
ENST00000560881
ENST00000559463	ENSP00000453319
ENST00000558131	ENSP00000453285
ENST00000558752	ENSP00000453584

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0030425	dendrite
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome