Version 5.4
Homo sapiens Gene: RNF168
Summary
InnateDB Gene IDBG-71203.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF168
Gene Name ring finger protein 168, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163961
Encoded Proteins
IDBP-71205
ring finger protein 168
IDBP-387085
ring finger protein 168
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:196468783-196503768
Strand Reverse strand
Band q29
Transcripts
ENST00000318037 ENSP00000320898
ENST00000437070 ENSP00000396712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein-Protein 40 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031491 nucleosome binding
GO:0042393 histone binding
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0070530 K63-linked polyubiquitin binding
Biological Process
GO:0006302 double-strand break repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0010212 response to ionizing radiation
GO:0016567 protein ubiquitination
GO:0035518 histone H2A monoubiquitination
GO:0036297 interstrand cross-link repair
GO:0036351 histone H2A-K13 ubiquitination
GO:0036352 histone H2A-K15 ubiquitination
GO:0045190 isotype switching
GO:0045739 positive regulation of DNA repair
GO:0045900 negative regulation of translational elongation
GO:0070534 protein K63-linked ubiquitination
GO:0070535 histone H2A K63-linked ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0035861 site of double-strand break
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014074
View Gene Order
ENSBTAG00000013317
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8IYW5
TrEMBL F8WD60
UniProt Splice Variant
Entrez Gene 165918
UniGene Hs.250648 Hs.727293 Hs.727426
RefSeq NM_152617
HUGO HGNC:26661
OMIM 612688
CCDS CCDS3317
HPRD
IMGT
EMBL AC092933 AC117490 AK054732 AK093113 BC033791
GenPept AAH33791 BAB70801 BAC04060
RNA Seq Atlas 165918

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca