Version 5.4
Homo sapiens Gene: FBXO45
Summary
InnateDB Gene IDBG-71251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO45
Gene Name F-box protein 45
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174013
Encoded Proteins
IDBP-71253
F-box protein 45
IDBP-387104
F-box protein 45
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:196568611-196589059
Strand Forward strand
Band q29
Transcripts
ENST00000311630 ENSP00000310332
ENST00000440469 ENSP00000389868
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001764 neuron migration
GO:0006974 cellular response to DNA damage stimulus
GO:0007399 nervous system development
GO:0016567 protein ubiquitination
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021800 cerebral cortex tangential migration
GO:0021957 corticospinal tract morphogenesis
GO:0021960 anterior commissure morphogenesis
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0060384 innervation
GO:0060386 synapse assembly involved in innervation
Cellular Component
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0042734 presynaptic membrane
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035764
View Gene Order
ENSBTAG00000006388
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt P0C2W1
TrEMBL C9JLC0
UniProt Splice Variant
Entrez Gene 200933
UniGene Hs.169815 Hs.599296 Hs.622375
RefSeq NM_001105573
HUGO HGNC:29148
OMIM 609112
CCDS CCDS46985
HPRD
IMGT
EMBL AC092933 AK025697 CH471191
GenPept EAW53643 EAW53644
RNA Seq Atlas 200933

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca