Version 5.4
Homo sapiens Gene: NCBP2
Summary
InnateDB Gene IDBG-71402.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCBP2
Gene Name nuclear cap binding protein subunit 2, 20kDa
Synonyms CBC2; CBP20; NIP1
Species Homo sapiens
Ensembl Gene ENSG00000114503
Encoded Proteins
IDBP-71404
nuclear cap binding protein subunit 2, 20kDa
IDBP-387134
nuclear cap binding protein subunit 2, 20kDa
IDBP-387138
nuclear cap binding protein subunit 2, 20kDa
IDBP-387140
nuclear cap binding protein subunit 2, 20kDa
IDBP-387141
nuclear cap binding protein subunit 2, 20kDa
IDBP-387142
nuclear cap binding protein subunit 2, 20kDa
IDBP-387143
nuclear cap binding protein subunit 2, 20kDa
IDBP-387144
nuclear cap binding protein subunit 2, 20kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5\' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3\'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:196935402-196942597
Strand Reverse strand
Band q29
Transcripts
ENST00000321256 ENSP00000326806
ENST00000427641 ENSP00000397619
ENST00000447325 ENSP00000413518
ENST00000452404 ENSP00000412785
ENST00000428425 ENSP00000414122
ENST00000422610 ENSP00000394105
ENST00000411704 ENSP00000389315
ENST00000455953 ENSP00000402549
ENST00000467803
ENST00000463783
ENST00000468923
ENST00000479647
ENST00000482976
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 25 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000339 RNA cap binding
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0006406 mRNA export from nucleus
GO:0006408 snRNA export from nucleus
GO:0006446 regulation of translational initiation
GO:0008334 histone mRNA metabolic process
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031047 gene silencing by RNA
GO:0031124 mRNA 3'-end processing
GO:0034660 ncRNA metabolic process
GO:0045292 mRNA cis splicing, via spliceosome
GO:0046833 positive regulation of RNA export from nucleus
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
GO:0005846 nuclear cap binding complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022774
View Gene Order
ENSBTAG00000008873
Not yet available
Pathways
NETPATH
REACTOME
REACT_11066
snRNP Assembly pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_185
SLBP independent Processing of Histone Pre-mRNAs pathway
REACT_1096
Processing of Intronless Pre-mRNAs pathway
REACT_1364
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs pathway
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_424
Transport of the SLBP independent Mature mRNA pathway
REACT_405
Transport of the SLBP Dependant Mature mRNA pathway
REACT_1835
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1470
mRNA Capping pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6261
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_6256
HIV Life Cycle pathway
REACT_11052
Metabolism of non-coding RNA pathway
REACT_1768
Processing of Capped Intronless Pre-mRNA pathway
REACT_338
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_6185
HIV Infection pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8WE41
UniProt Splice Variant
Entrez Gene 22916
UniGene Hs.591671 Hs.732137
RefSeq NM_001042540 NM_007362 XM_005269313
HUGO HGNC:7659
OMIM 605133
CCDS CCDS3323 CCDS46986
HPRD 05503
IMGT
EMBL AC011322
GenPept
RNA Seq Atlas 22916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca