InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CARD11

Summary

InnateDB Gene

IDBG-7145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CARD11

Gene Name

caspase recruitment domain family, member 11

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000198286

Encoded Proteins

IDBP-7147

caspase recruitment domain family, member 11

IDBP-7149

caspase recruitment domain family, member 11

IDBP-236412

caspase recruitment domain family, member 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:2906141-3043945

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000355508	ENSP00000347695
ENST00000356408	ENSP00000348779
ENST00000396946	ENSP00000380150
ENST00000480332

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	41 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0005515	protein binding
GO:0050700	CARD domain binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0007165	signal transduction
GO:0030890	positive regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045061	thymic T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0045577	regulation of B cell differentiation
GO:0045580	regulation of T cell differentiation
GO:0046939	nucleotide phosphorylation
GO:0050776	regulation of immune response
GO:0050852	T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0001772	immunological synapse
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0042101	T cell receptor complex
GO:0045121	membrane raft