Homo sapiens Gene: HIST1H2AD
InnateDB Gene IDBG-71465.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H2AD
Gene Name histone cluster 1, H2ad
Synonyms H2A.3; H2A/g; H2AFG
Species Homo sapiens
Ensembl Gene ENSG00000196866
Encoded Proteins
histone cluster 1, H2ad
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26198851-26199243
Strand Reverse strand
Band p22.2
ENST00000341023 ENSP00000341094
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 28 [view]
Protein-DNA 3 [view]
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0008150 biological_process
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
No orthologs found for this gene
Meiotic synapsis pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Packaging Of Telomere Ends pathway
Amyloids pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Opening pathway
Meiotic recombination pathway
HATs acetylate histones pathway
Cellular responses to stress pathway
PRC2 methylates histones and DNA pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNA Polymerase I Transcription pathway
Signaling by WNT in cancer pathway
Condensation of Prophase Chromosomes pathway
Signaling by Wnt pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Telomere Maintenance pathway
Signal Transduction pathway
SIRT1 negatively regulates rRNA Expression pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
HDACs deacetylate histones pathway
DNA methylation pathway
M Phase pathway
Cellular Senescence pathway
TCF dependent signaling in response to WNT pathway
Chromatin organization pathway
Mitotic Prophase pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Meiosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
Systemic lupus erythematosus pathway
SwissProt P20671
UniProt Splice Variant
Entrez Gene 3013
RefSeq NM_021065
OMIM 602792
HPRD 07534
EMBL AL031777 AY131985 BC093807 BC093809 BC128035 CR541970 CR541999 X16495 Z80776
GenPept AAH93807 AAH93809 AAI28036 AAN59966 CAA34511 CAB02538 CAB39197 CAG46768 CAG46796
RNA Seq Atlas 3013