InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DLG1

Summary

InnateDB Gene

IDBG-71508.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG1

Gene Name

discs, large homolog 1 (Drosophila)

Synonyms

dJ1061C18.1.1; DLGH1; hdlg; SAP-97; SAP97

Species

Homo sapiens

Ensembl Gene

ENSG00000075711

Encoded Proteins

IDBP-71510

discs, large homolog 1 (Drosophila)

IDBP-71514

discs, large homolog 1 (Drosophila)

IDBP-245766

discs, large homolog 1 (Drosophila)

IDBP-245768

discs, large homolog 1 (Drosophila)

IDBP-245770

discs, large homolog 1 (Drosophila)

IDBP-387197

discs, large homolog 1 (Drosophila)

IDBP-387199

discs, large homolog 1 (Drosophila)

IDBP-387200

discs, large homolog 1 (Drosophila)

IDBP-387201

discs, large homolog 1 (Drosophila)

IDBP-387202

discs, large homolog 1 (Drosophila)

IDBP-387204

discs, large homolog 1 (Drosophila)

IDBP-387205

discs, large homolog 1 (Drosophila)

IDBP-387212

discs, large homolog 1 (Drosophila)

IDBP-387214

discs, large homolog 1 (Drosophila)

IDBP-387217

discs, large homolog 1 (Drosophila)

IDBP-387218

discs, large homolog 1 (Drosophila)

IDBP-387219

discs, large homolog 1 (Drosophila)

IDBP-387220

discs, large homolog 1 (Drosophila)

IDBP-387221

discs, large homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:197042560-197299300

Strand

Reverse strand

Band

q29

Transcripts

ENST00000346964	ENSP00000345731
ENST00000357674	ENSP00000350303
ENST00000392382	ENSP00000376187
ENST00000392381	ENSP00000376186
ENST00000392380	ENSP00000376185
ENST00000448528	ENSP00000391732
ENST00000419354	ENSP00000407531
ENST00000452595	ENSP00000398939
ENST00000422288	ENSP00000413238
ENST00000443183	ENSP00000396658
ENST00000450955	ENSP00000411278
ENST00000419227	ENSP00000396768
ENST00000447466	ENSP00000398702
ENST00000453607	ENSP00000412579
ENST00000456699	ENSP00000396474
ENST00000419553	ENSP00000414189
ENST00000436682	ENSP00000393771
ENST00000412364	ENSP00000390403
ENST00000434148	ENSP00000400169
ENST00000469371
ENST00000475394
ENST00000470629
ENST00000471733
ENST00000493937
ENST00000477312
ENST00000485409
ENST00000469073
ENST00000486877

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	81 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008092	cytoskeletal protein binding
GO:0015459	potassium channel regulator activity
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0032947	protein complex scaffold
GO:0044325	ion channel binding
GO:0097016	L27 domain binding

Biological Process

GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001771	immunological synapse formation
GO:0001935	endothelial cell proliferation
GO:0002088	lens development in camera-type eye
GO:0002369	T cell cytokine production
GO:0007015	actin filament organization
GO:0007093	mitotic cell cycle checkpoint
GO:0007163	establishment or maintenance of cell polarity
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0008104	protein localization
GO:0008284	positive regulation of cell proliferation
GO:0016032	viral process
GO:0016311	dephosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0030432	peristalsis
GO:0030838	positive regulation of actin filament polymerization
GO:0030866	cortical actin cytoskeleton organization
GO:0031579	membrane raft organization
GO:0031641	regulation of myelination
GO:0032147	activation of protein kinase activity
GO:0042110	T cell activation
GO:0042130	negative regulation of T cell proliferation
GO:0042391	regulation of membrane potential
GO:0042982	amyloid precursor protein metabolic process
GO:0043268	positive regulation of potassium ion transport
GO:0045930	negative regulation of mitotic cell cycle
GO:0046939	nucleotide phosphorylation
GO:0048608	reproductive structure development
GO:0048704	embryonic skeletal system morphogenesis
GO:0048729	tissue morphogenesis
GO:0048745	smooth muscle tissue development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051898	negative regulation of protein kinase B signaling
GO:0060022	hard palate development
GO:0070830	tight junction assembly
GO:0072659	protein localization to plasma membrane
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:1902305	regulation of sodium ion transmembrane transport

Cellular Component

GO:0001772	immunological synapse
GO:0005605	basal lamina
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0009898	cytoplasmic side of plasma membrane
GO:0014069	postsynaptic density
GO:0014704	intercalated disc
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction
GO:0031253	cell projection membrane
GO:0031594	neuromuscular junction
GO:0033268	node of Ranvier
GO:0035748	myelin sheath abaxonal region
GO:0042383	sarcolemma
GO:0043219	lateral loop
GO:0045121	membrane raft
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097025	MPP7-DLG1-LIN7 complex