Version 5.4
Homo sapiens Gene: HBQ1
Summary
InnateDB Gene IDBG-7166.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HBQ1
Gene Name hemoglobin, theta 1
Synonyms HBQ
Species Homo sapiens
Ensembl Gene ENSG00000086506
Encoded Proteins
IDBP-7168
hemoglobin, theta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]
Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5\' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3\'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:180453-181181
Strand Forward strand
Band p13.3
Transcripts
ENST00000199708 ENSP00000199708
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005344 oxygen transporter activity
GO:0005506 iron ion binding
GO:0019825 oxygen binding
GO:0020037 heme binding
Biological Process
GO:0015671 oxygen transport
Cellular Component
GO:0005833 hemoglobin complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P09105
TrEMBL
UniProt Splice Variant
Entrez Gene 3049
UniGene Hs.247921
RefSeq NM_005331
HUGO HGNC:4833
OMIM 142240
CCDS CCDS10400
HPRD 00791
IMGT
EMBL AE006462 BC056686 DQ431198 M33022 M91453 X06482
GenPept AAA52640 AAA58362 AAH56686 AAK61217 ABD95912 CAA29776
RNA Seq Atlas 3049

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca