Version 5.4
Homo sapiens Gene: NMI
Summary
InnateDB Gene IDBG-72072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NMI
Gene Name N-myc (and STAT) interactor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000123609
Encoded Proteins
IDBP-72074
N-myc (and STAT) interactor
IDBP-386424
N-myc (and STAT) interactor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:151270465-151290057
Strand Reverse strand
Band q23.3
Transcripts
ENST00000243346 ENSP00000243346
ENST00000414946 ENSP00000387373
ENST00000491771
ENST00000477072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0007259 JAK-STAT cascade
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026946
View Gene Order
ENSBTAG00000032369
Not yet available
Pathways
NETPATH
NetPath_14
IL2 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.54483 Hs.605931
RefSeq NM_004688 XM_005246941
HUGO
OMIM
CCDS CCDS2192
HPRD 04632
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca