Homo sapiens Gene: NMI
Summary
InnateDB Gene IDBG-72072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NMI
Gene Name N-myc (and STAT) interactor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000123609
Encoded Proteins
N-myc (and STAT) interactor
N-myc (and STAT) interactor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:151270465-151290057
Strand Reverse strand
Band q23.3
Transcripts
ENST00000243346 ENSP00000243346
ENST00000414946 ENSP00000387373
ENST00000491771
ENST00000477072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0007259 JAK-STAT cascade
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL2 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
Il-2 receptor beta chain in t cell activation [Biocarta view]
Il-7 signal transduction [Biocarta view]
PID NCI
Cross-References
SwissProt Q13287
TrEMBL C9JW17
UniProt Splice Variant
Entrez Gene 9111
UniGene Hs.54483 Hs.605931
RefSeq NM_004688 XM_005246941
HUGO HGNC:7854
OMIM 603525
CCDS CCDS2192
HPRD 04632
IMGT
EMBL AB451305 AB451436 AC009311 BC001268 CH471058 U32849
GenPept AAC12949 AAH01268 AAY15066 BAG70119 BAG70250 EAX11513
RNA Seq Atlas 9111