Homo sapiens Gene: SOX10
Summary
InnateDB Gene IDBG-7212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX10
Gene Name SRY (sex determining region Y)-box 10
Synonyms DOM; PCWH; WS2E; WS4; WS4C;
Species Homo sapiens
Ensembl Gene ENSG00000100146
Encoded Proteins
SRY (sex determining region Y)-box 10
SRY (sex determining region Y)-box 10
SRY (sex determining region Y)-box 10
SRY (sex determining region Y)-box 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37970686-37987422
Strand Reverse strand
Band q13.1
Transcripts
ENST00000360880 ENSP00000354130
ENST00000396884 ENSP00000380093
ENST00000446929 ENSP00000399777
ENST00000427770 ENSP00000414853
ENST00000470555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0042802 identical protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001755 neural crest cell migration
GO:0002052 positive regulation of neuroblast proliferation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007422 peripheral nervous system development
GO:0009653 anatomical structure morphogenesis
GO:0014015 positive regulation of gliogenesis
GO:0030154 cell differentiation
GO:0030318 melanocyte differentiation
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0048484 enteric nervous system development
GO:0048546 digestive tract morphogenesis
GO:0048589 developmental growth
GO:0048709 oligodendrocyte differentiation
GO:0048863 stem cell differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031315 extrinsic component of mitochondrial outer membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.376984
RefSeq NM_006941
HUGO
OMIM
CCDS CCDS13964
HPRD 03752
IMGT
EMBL
GenPept
RNA Seq Atlas