Homo sapiens Gene: GPX6
Summary
InnateDB Gene IDBG-72122.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPX6
Gene Name glutathione peroxidase 6 (olfactory)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198704
Encoded Proteins
glutathione peroxidase 6 (olfactory)
glutathione peroxidase 6 (olfactory)
glutathione peroxidase 6 (olfactory)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:28503296-28528215
Strand Reverse strand
Band p22.1
Transcripts
ENST00000361902 ENSP00000354581
ENST00000474923 ENSP00000417364
ENST00000483058
ENST00000612264 ENSP00000483462
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Glutathione metabolism pathway
Arachidonic acid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P59796
TrEMBL A3KN74
UniProt Splice Variant
Entrez Gene 257202
UniGene Hs.448570 Hs.691056
RefSeq NM_182701
HUGO HGNC:4558
OMIM 607913
CCDS CCDS43432
HPRD
IMGT
EMBL AL049543 AY324826 BC133691 CH471081 DQ088982 Z98745
GenPept AAI33692 AAP85543 AAY68223 EAX03167
RNA Seq Atlas 257202