Version 5.4
Homo sapiens Gene: ARL5A
Summary
InnateDB Gene IDBG-72355.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL5A
Gene Name ADP-ribosylation factor-like 5A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162980
Encoded Proteins
IDBP-72357
ADP-ribosylation factor-like 5A
IDBP-386558
ADP-ribosylation factor-like 5A
IDBP-386560
ADP-ribosylation factor-like 5A
IDBP-386562
ADP-ribosylation factor-like 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:151788984-151828492
Strand Reverse strand
Band q23.3
Transcripts
ENST00000295087 ENSP00000295087
ENST00000446896 ENSP00000394626
ENST00000428992 ENSP00000415950
ENST00000458140 ENSP00000393716
ENST00000495604
ENST00000487818
ENST00000487723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036093
View Gene Order
ENSBTAG00000002293
Not yet available
Cross-References
SwissProt Q9Y689
TrEMBL F8WER2
UniProt Splice Variant
Entrez Gene 26225
UniGene Hs.470233 Hs.598543 Hs.609384 Hs.617369
RefSeq NM_001037174 NM_012097 NM_177985
HUGO HGNC:696
OMIM 608960
CCDS CCDS2195 CCDS46425
HPRD
IMGT
EMBL AC097448 AF087889 AF100740 AF493891 AK292714 BC001254 BT009829 CH471058 CR613929
GenPept AAD40383 AAH01254 AAM12605 AAP88831 AAP97188 AAX82013 BAF85403 EAX11495 EAX11496
RNA Seq Atlas 101929356 26225

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca