InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC25A10

Summary

InnateDB Gene

IDBG-72582.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A10

Gene Name

solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000183048

Encoded Proteins

IDBP-72584

solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

IDBP-72586

solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

IDBP-595508

solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

IDBP-600079

solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

IDBP-758114

IDBP-758133

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81712236-81721016

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000331531	ENSP00000328403
ENST00000350690	ENSP00000345580
ENST00000541223	ENSP00000439565
ENST00000545862	ENSP00000446242
ENST00000571876
ENST00000574884	ENSP00000458785
ENST00000573246
ENST00000574129	ENSP00000460597
ENST00000570310

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005310	dicarboxylic acid transmembrane transporter activity
GO:0005515	protein binding

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0000098	sulfur amino acid catabolic process
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006811	ion transport
GO:0006835	dicarboxylic acid transport
GO:0006839	mitochondrial transport
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0070221	sulfide oxidation, using sulfide:quinone oxidoreductase