InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APOA1

Summary

InnateDB Gene

IDBG-72644.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOA1

Gene Name

apolipoprotein A-I

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000118137

Encoded Proteins

IDBP-72646

apolipoprotein A-I

IDBP-72648

apolipoprotein A-I

IDBP-72650

apolipoprotein A-I

IDBP-72652

apolipoprotein A-I

IDBP-72654

apolipoprotein A-I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20519121

APOA1 is a serum apolipoprotein that induces antiatherogenic efflux of macrophage cholesterol and is anti-inflammatory due to its ability to neutralize bacterial lipopolysaccharide (LPS). APOA1 also signals in the macrophage through Toll-like receptor (TLR)2, TLR4, and CD14, utilizing MYD88-dependent and -independent pathways, to activate nuclear factor-kappaB and induce cytokines.

PMID 22271762

APOA1 has anti-inflammatory properties in macrophages through the stabilization of ATP-binding cassette transporter A1 (ABCA1) and the down-regulation of TLR4 signalling pathway.

InnateDB Annotation from Orthologs

Summary

PMID 22271762

[Mus musculus] Apoa1 has anti-inflammatory properties in macrophages through the stabilization of ATP-binding cassette transporter A1 (Abca1) and the down-regulation of Tlr4 signalling pathway. (Demonstrated in human)

Entrez Gene

Summary

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:116835751-116837950

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000375329	ENSP00000364478
ENST00000375323	ENSP00000364472
ENST00000359492	ENSP00000352471
ENST00000375320	ENSP00000364469
ENST00000236850	ENSP00000236850

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	86 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0005548	phospholipid transporter activity
GO:0008035	high-density lipoprotein particle binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0017127	cholesterol transporter activity
GO:0019899	enzyme binding
GO:0034190	apolipoprotein receptor binding
GO:0034191	apolipoprotein A-I receptor binding
GO:0042802	identical protein binding
GO:0055102	lipase inhibitor activity
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653	high-density lipoprotein particle receptor binding
GO:0071813	lipoprotein particle binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0001932	regulation of protein phosphorylation
GO:0001935	endothelial cell proliferation
GO:0002576	platelet degranulation
GO:0002740	negative regulation of cytokine secretion involved in immune response
GO:0006644	phospholipid metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0006869	lipid transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0007596	blood coagulation
GO:0007603	phototransduction, visible light
GO:0008203	cholesterol metabolic process
GO:0008211	glucocorticoid metabolic process
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010873	positive regulation of cholesterol esterification
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling
GO:0014012	peripheral nervous system axon regeneration
GO:0015914	phospholipid transport
GO:0018158	protein oxidation
GO:0018206	peptidyl-methionine modification
GO:0019915	lipid storage
GO:0030168	platelet activation
GO:0030300	regulation of intestinal cholesterol absorption
GO:0030301	cholesterol transport
GO:0030325	adrenal gland development
GO:0031100	organ regeneration
GO:0032489	regulation of Cdc42 protein signal transduction
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0034375	high-density lipoprotein particle remodeling
GO:0034380	high-density lipoprotein particle assembly
GO:0034384	high-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0042158	lipoprotein biosynthetic process
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0043534	blood vessel endothelial cell migration
GO:0043627	response to estrogen
GO:0043691	reverse cholesterol transport
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050713	negative regulation of interleukin-1 beta secretion
GO:0050728	negative regulation of inflammatory response
GO:0050821	protein stabilization
GO:0051345	positive regulation of hydrolase activity
GO:0051346	negative regulation of hydrolase activity
GO:0051347	positive regulation of transferase activity
GO:0055085	transmembrane transport
GO:0055091	phospholipid homeostasis
GO:0060192	negative regulation of lipase activity
GO:0060354	negative regulation of cell adhesion molecule production
GO:0060761	negative regulation of response to cytokine stimulus
GO:0070328	triglyceride homeostasis
GO:0070508	cholesterol import

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005769	early endosome
GO:0005788	endoplasmic reticulum lumen
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0030139	endocytic vesicle
GO:0031410	cytoplasmic vesicle
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0034365	discoidal high-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0034774	secretory granule lumen
GO:0070062	extracellular vesicular exosome
GO:0071682	endocytic vesicle lumen
GO:0072562	blood microparticle