Version 5.4
Homo sapiens Gene: TLE4
Summary
InnateDB Gene IDBG-72733.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLE4
Gene Name transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
Synonyms BCE-1; BCE1; E(spI); ESG; ESG4; GRG4
Species Homo sapiens
Ensembl Gene ENSG00000106829
Encoded Proteins
IDBP-72735
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-72737
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-72739
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-72743
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-373806
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-373807
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-373815
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-373816
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-373818
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-483058
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-475804
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-475534
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-479563
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-478160
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
IDBP-482710
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:79571773-79726882
Strand Forward strand
Band q21.31
Transcripts
ENST00000376552 ENSP00000365735
ENST00000265284 ENSP00000265284
ENST00000376544 ENSP00000365727
ENST00000376537 ENSP00000365720
ENST00000376525
ENST00000376524
ENST00000435650 ENSP00000415423
ENST00000414465 ENSP00000397822
ENST00000425506 ENSP00000412567
ENST00000428713 ENSP00000409313
ENST00000455913
ENST00000417836 ENSP00000400334
ENST00000461758 ENSP00000417906
ENST00000470872 ENSP00000417245
ENST00000462803 ENSP00000417715
ENST00000476523
ENST00000485159
ENST00000466428
ENST00000496853
ENST00000474519
ENST00000483597
ENST00000490347 ENSP00000417844
ENST00000493163
ENST00000463431
ENST00000495170
ENST00000467142 ENSP00000418409
ENST00000496114 ENSP00000417102
ENST00000478290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003682 chromatin binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007219 Notch signaling pathway
GO:0008150 biological_process
GO:0016055 Wnt signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024642
View Gene Order
ENSBTAG00000003532
Not yet available
Pathways
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_228106
repression of WNT target genes pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596760 Hs.600735 Hs.628997
RefSeq NM_001282748 NM_001282749 NM_001282753 NM_001282760 NM_007005
HUGO
OMIM
CCDS CCDS43837 CCDS65069 CCDS65070 CCDS75851
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca