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InnateDB Gene
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IDBG-7284.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TDH
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Gene Name
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L-threonine dehydrogenase
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Synonyms
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000154316
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Encoded Proteins
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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| Summary |
This gene appears to be an evolving pseudogene of L-threonine 3-dehydrogenase (TDH). In both prokaryotes and eukaryotes, TDH catalyzes the first of two steps in one of two L-threonine degradation pathways. However, in human, the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted protein lacks most of the C-terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins. This suggests that the human gene is therefore a pseudogene. Transcripts of this gene are found in all tissues and alternatively spliced transcripts have been described. It is not known if these transcripts are translated, or if the possible protein product provides any functional role. [provided by RefSeq, Jul 2008]
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| Type |
unitary_pseudogene
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Genomic Location
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Chromosome 8:11339637-11368452
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Strand
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Forward strand
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Band
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p23.1
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
1
[view]
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| Protein-Protein |
1
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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No orthologs found for this gene |
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SwissProt
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
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UniGene
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Hs.583896
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RefSeq
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HUGO
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OMIM
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CCDS
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| HPRD |
10264
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IMGT
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EMBL
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GenPept
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RNA Seq Atlas
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Version 5.4