Version 5.4
Homo sapiens Gene: null
Summary
InnateDB Gene IDBG-728859.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol null
Gene Name
Synonyms HHO.C1; Hox-2.3; HOX2; HOX2C
Species Homo sapiens
Ensembl Gene ENSG00000260027
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48607227-48633572
Strand Reverse strand
Band q21.32
Transcripts
ENST00000567101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0009952 anterior/posterior pattern specification
GO:0030099 myeloid cell differentiation
GO:0048704 embryonic skeletal system morphogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P09629
TrEMBL Q9HB12
UniProt Splice Variant
Entrez Gene 3217
UniGene Hs.608642 Hs.629601
RefSeq NM_004502
HUGO HGNC:5118
OMIM 142962
CCDS CCDS11532
HPRD
IMGT
EMBL AC103702 AF287967 AK223249 AK290653 BC015345 CH471109 M16937 M30598 S49765
GenPept AAA36003 AAA36005 AAB19469 AAG31551 AAH15345 BAD96969 BAF83342 EAW94725
RNA Seq Atlas 3217

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca