Version 5.4
Homo sapiens Gene: PKP4
Summary
InnateDB Gene IDBG-73053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKP4
Gene Name plakophilin 4
Synonyms p0071
Species Homo sapiens
Ensembl Gene ENSG00000144283
Encoded Proteins
IDBP-73055
plakophilin 4
IDBP-73057
plakophilin 4
IDBP-386800
plakophilin 4
IDBP-386801
plakophilin 4
IDBP-386802
plakophilin 4
IDBP-386803
plakophilin 4
IDBP-386804
plakophilin 4
IDBP-600971
plakophilin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila \'armadillo\' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:158456964-158682879
Strand Forward strand
Band q24.1
Transcripts
ENST00000389759 ENSP00000374409
ENST00000389757 ENSP00000374407
ENST00000426248 ENSP00000396827
ENST00000457109 ENSP00000391658
ENST00000452162 ENSP00000407218
ENST00000411900 ENSP00000392515
ENST00000421462 ENSP00000393872
ENST00000479398
ENST00000462335
ENST00000481115 ENSP00000437815
ENST00000494945
ENST00000492496
ENST00000480171
ENST00000495123
ENST00000483881
ENST00000486254
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007043 cell-cell junction assembly
GO:0007267 cell-cell signaling
GO:0010628 positive regulation of gene expression
GO:0016337 single organismal cell-cell adhesion
GO:0030155 regulation of cell adhesion
GO:0032321 positive regulation of Rho GTPase activity
GO:0032467 positive regulation of cytokinesis
Cellular Component
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0009898 cytoplasmic side of plasma membrane
GO:0030057 desmosome
GO:0030496 midbody
GO:0044291 cell-cell contact zone
GO:0048471 perinuclear region of cytoplasm
GO:0051233 spindle midzone
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026991
View Gene Order
ENSBTAG00000013773
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.407580
RefSeq NM_001005476 NM_003628
HUGO
OMIM
CCDS CCDS33305 CCDS33306
HPRD 05043
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca