Homo sapiens Gene: RAC3
Summary
InnateDB Gene IDBG-73067.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAC3
Gene Name ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169750
Encoded Proteins
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:82031624-82034204
Strand Forward strand
Band q25.3
Transcripts
ENST00000306897 ENSP00000304283
ENST00000584341 ENSP00000462421
ENST00000585014
ENST00000580965 ENSP00000463590
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0030031 cell projection assembly
GO:0030036 actin cytoskeleton organization
GO:0031175 neuron projection development
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035556 intracellular signal transduction
GO:0050885 neuromuscular process controlling balance
GO:0050905 neuromuscular process
GO:0051056 regulation of small GTPase mediated signal transduction
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0031941 filamentous actin
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
PCP/CE pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by Rho GTPases pathway
Signal Transduction pathway
Rho GTPase cycle pathway
KEGG
MAPK signaling pathway pathway
Wnt signaling pathway pathway
Axon guidance pathway
VEGF signaling pathway pathway
Focal adhesion pathway
Adherens junction pathway
Natural killer cell mediated cytotoxicity pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Colorectal cancer pathway
Pancreatic cancer pathway
Viral myocarditis pathway
INOH
CD4 T cell receptor signaling pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_005052 XM_005256390
HUGO
OMIM
CCDS CCDS11798
HPRD 03629
IMGT
EMBL
GenPept
RNA Seq Atlas