Version 5.4
Homo sapiens Gene: ASB12
Summary
InnateDB Gene IDBG-73147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASB12
Gene Name ankyrin repeat and SOCS box containing 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198881
Encoded Proteins
IDBP-73151
ankyrin repeat and SOCS box containing 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:64224196-64230631
Strand Reverse strand
Band q11.2
Transcripts
ENST00000362002 ENSP00000355195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031204
View Gene Order
ENSBTAG00000007211
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8WXK4
TrEMBL
UniProt Splice Variant
Entrez Gene 142689
UniGene Hs.56281
RefSeq NM_130388
HUGO HGNC:19763
OMIM 300891
CCDS CCDS14378
HPRD
IMGT
EMBL AF403030 AK096896 AL356317 BC069436 BC069555 BC093883 BC104946 CH471132
GenPept AAH69436 AAH69555 AAH93883 AAI04947 AAL57349 BAC04888 CAI39932 EAX05414
RNA Seq Atlas 142689

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca