Homo sapiens Gene: FXYD2
Summary
InnateDB Gene IDBG-73303.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXYD2
Gene Name FXYD domain containing ion transport regulator 2
Synonyms ATP1G1; HOMG2;
Species Homo sapiens
Ensembl Gene ENSG00000137731
Encoded Proteins
FXYD domain containing ion transport regulator 2
FXYD domain containing ion transport regulator 2
FXYD domain containing ion transport regulator 2
FXYD domain containing ion transport regulator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:117800844-117828698
Strand Reverse strand
Band q23.3
Transcripts
ENST00000260287 ENSP00000260287
ENST00000292079 ENSP00000292079
ENST00000317594
ENST00000532119 ENSP00000436414
ENST00000528014 ENSP00000432430
ENST00000534383
ENST00000533281
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005216 ion channel activity
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0005515 protein binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042127 regulation of cell proliferation
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
Ion channel transport pathway
KEGG
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Proximal tubule bicarbonate reclamation pathway
Salivary secretion pathway
Pancreatic secretion pathway
Carbohydrate digestion and absorption pathway
Protein digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
Oxidative stress induced gene expression via nrf2 [Biocarta view]
PID NCI
Cross-References
SwissProt P54710
TrEMBL
UniProt Splice Variant
Entrez Gene 486
UniGene
RefSeq NM_021603 NM_001680
HUGO HGNC:4026
OMIM 601814
CCDS CCDS8385 CCDS8386
HPRD 03487
IMGT
EMBL AF241235 AF241236 AF316896 BC005302 BC013289 BT006721 U50743 X86400
GenPept AAB09425 AAG34359 AAG34360 AAG34361 AAG37906 AAG37907 AAH05302 AAH13289 AAP35367 CAA60152
RNA Seq Atlas 486