Version 5.4
Homo sapiens Gene: ZFP57
Summary
InnateDB Gene IDBG-73686.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFP57
Gene Name zinc finger protein 57 homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204644
Encoded Proteins
IDBP-73688
zinc finger protein 57 homolog (mouse)
IDBP-73690
zinc finger protein 57 homolog (mouse)
IDBP-484447
zinc finger protein 57 homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:29672392-29681110
Strand Reverse strand
Band p22.1
Transcripts
ENST00000376883 ENSP00000366080
ENST00000376881 ENSP00000366078
ENST00000488757 ENSP00000418259
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007422 peripheral nervous system development
GO:0043045 DNA methylation involved in embryo development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036036
View Gene Order
ENSBTAG00000017836
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.156326
RefSeq NM_001109809 XM_006715087 XM_006725485 XM_006725486 XM_006725487 XM_006725701 XM_006725818 XM_006725910 XM_006726000 XM_006726093
HUGO
OMIM
CCDS CCDS43436
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca