Version 5.4
Homo sapiens Gene: HNRNPK
Summary
InnateDB Gene IDBG-73948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPK
Gene Name heterogeneous nuclear ribonucleoprotein K
Synonyms CSBP; HNRPK; TUNP
Species Homo sapiens
Ensembl Gene ENSG00000165119
Encoded Proteins
IDBP-73950
heterogeneous nuclear ribonucleoprotein K
IDBP-73954
heterogeneous nuclear ribonucleoprotein K
IDBP-73958
heterogeneous nuclear ribonucleoprotein K
IDBP-73960
heterogeneous nuclear ribonucleoprotein K
IDBP-374216
heterogeneous nuclear ribonucleoprotein K
IDBP-812095
heterogeneous nuclear ribonucleoprotein K
IDBP-812100
heterogeneous nuclear ribonucleoprotein K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:83968083-83980616
Strand Reverse strand
Band q21.32
Transcripts
ENST00000376281 ENSP00000365458
ENST00000351839 ENSP00000317788
ENST00000376263 ENSP00000365439
ENST00000360384 ENSP00000353552
ENST00000376256
ENST00000457156 ENSP00000409456
ENST00000493362
ENST00000492865
ENST00000481820 ENSP00000473957
ENST00000472778 ENSP00000475098
ENST00000483135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 279 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 279 [view]
Protein-Protein 273 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006396 RNA processing
GO:0007165 signal transduction
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0010988 regulation of low-density lipoprotein particle clearance
GO:0016032 viral process
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000790 nuclear chromatin
GO:0002102 podosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030054 cell junction
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021546
View Gene Order
ENSBTAG00000021131
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.522257 Hs.729980
RefSeq NM_002140 NM_031262 NM_031263 XM_005251960 XM_005251961
HUGO
OMIM
CCDS CCDS6667 CCDS6668
HPRD 02834
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca