Version 5.4
Homo sapiens Gene: SCN3A
Summary
InnateDB Gene IDBG-73968.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCN3A
Gene Name sodium channel, voltage-gated, type III, alpha subunit
Synonyms NAC3; Nav1.3
Species Homo sapiens
Ensembl Gene ENSG00000153253
Encoded Proteins
IDBP-73970
sodium channel, voltage-gated, type III, alpha subunit
IDBP-73972
sodium channel, voltage-gated, type III, alpha subunit
IDBP-293819
sodium channel, voltage-gated, type III, alpha subunit
IDBP-387148
sodium channel, voltage-gated, type III, alpha subunit
IDBP-387151
sodium channel, voltage-gated, type III, alpha subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:165087522-165204067
Strand Reverse strand
Band q24.3
Transcripts
ENST00000283254 ENSP00000283254
ENST00000360093 ENSP00000353206
ENST00000409101 ENSP00000386726
ENST00000440431 ENSP00000403348
ENST00000453007 ENSP00000391569
ENST00000465043
ENST00000471697
ENST00000484898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0019228 neuronal action potential
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057182
View Gene Order
ENSBTAG00000019385
Not yet available
Pathways
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.435274
RefSeq NM_001081676 NM_001081677 NM_006922 XM_006712679
HUGO
OMIM
CCDS CCDS33312 CCDS46440
HPRD 01671
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca