Version 5.4
Homo sapiens Gene: PJA1
Summary
InnateDB Gene IDBG-74069.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PJA1
Gene Name praja ring finger 1, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000181191
Encoded Proteins
IDBP-74071
praja ring finger 1
IDBP-74073
praja ring finger 1
IDBP-74075
praja ring finger 1
IDBP-74077
praja ring finger 1
IDBP-713542
IDBP-713451
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:69160851-69165793
Strand Reverse strand
Band q13.1
Transcripts
ENST00000374584 ENSP00000363712
ENST00000374583 ENSP00000363711
ENST00000361478 ENSP00000355014
ENST00000374571 ENSP00000363699
ENST00000471141 ENSP00000467564
ENST00000477231
ENST00000590146 ENSP00000467404
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000034403
View Gene Order
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7EPI8
UniProt Splice Variant
Entrez Gene 64219
UniGene Hs.522679
RefSeq NM_001032396 NM_022368 NM_145119 XM_005262292
HUGO HGNC:16648
OMIM 300420
CCDS CCDS14392 CCDS14393 CCDS35316
HPRD 02335
IMGT
EMBL AL157699
GenPept
RNA Seq Atlas 64219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca