Homo sapiens Gene: NTRK2
Summary
InnateDB Gene IDBG-74210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTRK2
Gene Name neurotrophic tyrosine kinase, receptor, type 2
Synonyms GP145-TrkB; trk-B; TRKB;
Species Homo sapiens
Ensembl Gene ENSG00000148053
Encoded Proteins
neurotrophic tyrosine kinase, receptor, type 2
neurotrophic tyrosine kinase, receptor, type 2
neurotrophic tyrosine kinase, receptor, type 2
neurotrophic tyrosine kinase, receptor, type 2
neurotrophic tyrosine kinase, receptor, type 2
neurotrophic tyrosine kinase, receptor, type 2
neurotrophic tyrosine kinase, receptor, type 2
neurotrophic tyrosine kinase, receptor, type 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:84668551-85027070
Strand Forward strand
Band q21.33
Transcripts
ENST00000376214 ENSP00000365387
ENST00000376213 ENSP00000365386
ENST00000277120 ENSP00000277120
ENST00000304053 ENSP00000306167
ENST00000376208 ENSP00000365381
ENST00000323115 ENSP00000314586
ENST00000359847 ENSP00000352906
ENST00000395882 ENSP00000379221
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005030 neurotrophin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0043121 neurotrophin binding
GO:0046875 ephrin receptor binding
GO:0048403 brain-derived neurotrophic factor binding
GO:0060175 brain-derived neurotrophic factor-activated receptor activity
Biological Process
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007528 neuromuscular junction development
GO:0007568 aging
GO:0007612 learning
GO:0007616 long-term memory
GO:0007623 circadian rhythm
GO:0007631 feeding behavior
GO:0008284 positive regulation of cell proliferation
GO:0009416 response to light stimulus
GO:0010628 positive regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0010996 response to auditory stimulus
GO:0014047 glutamate secretion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019222 regulation of metabolic process
GO:0021954 central nervous system neuron development
GO:0021987 cerebral cortex development
GO:0030182 neuron differentiation
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0032314 regulation of Rac GTPase activity
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0042490 mechanoreceptor differentiation
GO:0043408 regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0046548 retinal rod cell development
GO:0046777 protein autophosphorylation
GO:0046928 regulation of neurotransmitter secretion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048709 oligodendrocyte differentiation
GO:0048935 peripheral nervous system neuron development
GO:0050772 positive regulation of axonogenesis
GO:0050773 regulation of dendrite development
GO:0051896 regulation of protein kinase B signaling
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060291 long-term synaptic potentiation
GO:0071356 cellular response to tumor necrosis factor
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0014069 postsynaptic density
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043235 receptor complex
GO:0043679 axon terminus
GO:0045211 postsynaptic membrane
GO:0048786 presynaptic active zone
GO:0060076 excitatory synapse
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signalling by NGF pathway
NGF-independant TRKA activation pathway
Signal Transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
Activation of TRKA receptors pathway
KEGG
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Neurotrophic factor-mediated Trk receptor signaling
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt Q16620
TrEMBL Q8WXJ4 Q8WXJ8 S5MD53
UniProt Splice Variant
Entrez Gene 4915
UniGene Hs.494312 Hs.595176 Hs.712776
RefSeq NM_001018066 NM_006180 NM_001018065 NM_001007097 NM_001018064 XM_005252006 XM_005252004 XM_005252003 XM_005252001 XM_005252007
HUGO HGNC:8032
OMIM 600456
CCDS CCDS35052 CCDS6671 CCDS35051 CCDS35050 CCDS35053
HPRD 02712
IMGT
EMBL AB209118 AF410898 AF410899 AF410900 AF410901 AF410902 AF508964 AK294285 AL390777 AL445532 AL596132 BC031835 CH471089 KC855566 S76473 S76474 U12140 X75958
GenPept AAB33109 AAB33110 AAC51371 AAH31835 AAL67964 AAL67965 AAL67966 AAL67967 AAL67968 AAM77876 AGR50957 BAD92355 BAG57570 CAA53571 CAH71816 CAH72193 CAH72194 CAH72195 CAH72313 CAH72314 CAH72316 EAW62688
RNA Seq Atlas 4915